Saturday, March 22, 2008

HATI-HATI DENGAN MSG !!!


Monosodium L-glutamate-induced asthma


Ingested chemicals, including aspirin and sulfites, are becoming increasingly recognized as provokers of acute severe asthma. In order to investigate the asthma-provoking potential of the widely used flavor enhancer, monosodium L-glutamate (MSG), we challenged 32 subjects with asthma, a number of whom gave histories of severe asthma after Chinese restaurant meals or similarly spiced meals. The subjects received an additive-free diet for 5 days before challenge and were challenged in hospital, after an overnight fast, with 500 mg capsules of MSG. They were challenged in a single-blind, placebo-controlled fashion with increasing doses of MSG from 0.5 gm to 5.0 gm. Thirteen subjects reacted. Seven subjects (group 1) developed asthma and symptoms of the Chinese restaurant syndrome 1 to 2 hours after ingestion of MSG. Six subjects (group 2) did not develop symptoms of Chinese restaurant syndrome, and their asthma developed 6 to 12 hours after ingestion of MSG. These challenge studies confirm that MSG can provoke asthma. The reaction to MSG is dose dependent and may be delayed up to 12 hours, making recognition difficult for both patient and physician.

Reference:
PMID: 3312372 [PubMed - indexed for MEDLINE]

1 comment:

Anonymous said...

Setuju dengan penelitian yg anda post dari pubmed.

Yang hairannya, Why FDA (www.fda.gov) has set no limits on how much of it can be added to food. They claim it's safe to eat in any amount. But how can they claim it's safe when there are hundreds of scientific studies with titles like these:

# "The monosodium glutamate (MSG) obese rat as a model for the study of exercise in obesity." Gobatto CA, Mello MA, Souza CT, Ribeiro IA. Res Commun Mol Pathol Pharmacol. 2002.

# "Adrenalectomy abolishes the food-induced hypothalamic serotonin release in both normal and monosodium glutamate-obese rats." Guimaraes RB, Telles MM, Coelho VB, Mori C, Nascimento CM, Ribeiro. Brain Res Bull. 2002 Aug.

# "Obesity induced by neonatal monosodium glutamate treatment in spontaneously hypertensive rats: An animal model of multiple risk factors." Iwase M, Yamamoto M, Iino K, Ichikawa K, Shinohara N, Yoshinari Fujishima. Hypertens Res. 1998 Mar.

# "Hypothalamic lesion induced by injection of monosodium glutamate in suckling period and subsequent development of obesity." Tanaka K, Shimada M, Nakao K Kusunoki. Exp Neurol. 1978 Oct. No, the date of that last study was not a typo; it was published in 1978.

Takkan kita mahu menjadi tikus yang menjadi bahan eksperimen besar-besaran! Pihak FDA mesti membataskan penggunaan di restoran2 dunia yang telah ketagih dengan bahan beracun ini!...

TQ